CARDIAC OUTPUT (CO)-SOME INOTROPES
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SUMMARY
1. Catecholamines ⟹ via beta1 adrenoceptors ⟹ increase intracellular cAMP.
2. Xanthines (caffine, theophylline) ⟹ via inhibition of breakdown of cAMP ⟹ increase intracelular cAMP.
3. Digitalis ⟹ effect the Na/K-ATPase ⟹ decrease calcium removal from the cytosol.
Reference(s)
Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.
