AUTOREGULATION-HISTAMINE

SUMMARY

1. Derived from histidine, found in granules of basophils & mast cells.

2. Released in response to trauma & allergic reactions.

3. Functions: visceral smooth muscle contraction, vascular smooth muscle relaxation (through the action of NO), vasodilation, increased capillary permeability, attracts leukocytes.

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.