PAIN-METHADONE
From NeuroRehab.wiki
SUMMARY
1. Methadone is a potent NMDA receptor antagonist, NMDA activation has been implicated in neural plasticity (central sensitization) & as a mediator of opioid tolerance.
2. Methadone accumulates in tissues with repeated dosing, creating an extensive reservoir, and is highly protein-bound.
3. Half-life varies from 7 hours to 5 days.
4. Dosing changes must be done at least every 5 to 6 days.
Reference(s)
Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.
