PAIN-CHRONIC PAIN, OPIOIDS

SUMMARY

1. Good short term efficacy in both neuropathic and musculoskeletal pain.

2. Average pain reduction with long-term opioid therapy ~32%

3. No controlled study on opioid efficacy longer than 16 weeks.

4. No evidence beyond 6 months.

5. Daily doses of Morphine >180mg, or equivalent, have not been validated.

6. 80% of patients experienced at least one adverse event.

Reference(s)

1. Balantyne JC, Mao J. N Engl J Med. 2003:349;1943-1953 2. Turk DC. Clin J Pain. 2002;18:355-365 3. Lalso E. Edwards JE. Moore RA. McQuay HJ. Pain 2004; 112: 372-80
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O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.