PAIN-ASCENDING PATHWAY MECHANISMS

SUMMARY

1. Autonomic system response: fight-or-flight.

2. Activation of somatosensory cortices (S1–S2) provides information regarding the quality & intensity of pain.

3. Higher processing involves parietal & insular regions, contributing to an overall sense of intrusion and unpleasantness.

4. Convergence of pathways with frontal regions (anterior cingulate cortex): for attention & emotional valence of the pain experience.

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.