DEMENTIA TYPE-LEWY BODY DEMENTIA MGM

SUMMARY

1. Both the dementia and psychosis may be at least partially responsive to acetylcholinesterase inhibitors & memantine.

2. Poor response to the older antipsychotic drugs that block the D2 dopamine receptor (other than clozapine & quetiapine, which spare D2) including haloperidol and chlorpromazine: severe worsening of symptoms with extreme sedation, increased confusion, and postural instability with falls.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].