TBI-ANTIDEPRESSANTS FOR AGITATION

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SUMMARY

1. SSRI: Sertraline was shown in 3 studies to reduce irritability & aggressive behaviour but had no effect in another study.

2. TCA: Amitriptyline and desipramine have been shown to reduce agitation and aggressive behaviour possibly due to sedative effects.


Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.