PAIN-SHORT ACTING OPIOIDS

SUMMARY

1. Short-acting opioids include morphine, hydromorphone, and many combination opioid products (hydrocodone or oxycodone with acetaminophen or ibuprofen).

2. Tapentadol, approved by the FDA in 2009, is a short-acting opioid with a dual mechanism of action: traditional μ-agonist and norepinephrine reuptake inhibition.

3. Noradrenergic effects include increasing descending inhibition via blocking reuptake of norepinephrine centrally and/or norepinephrine effects more peripherally, limiting GIT adverse effects.

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.