NEUROPATHIC PAIN-SNRI

SUMMARY

1. Mirtazepine: potent α₂-adrenergic, 5-HT₂ & 5-HT₃ receptor antagonist and an enhancer of norepinephrine and serotonin neurotransmission. Uses: enhance the efficacy of SSRIs, enhances sleep.

2. Venlafaxine: potent dual reuptake inhibitor of serotonin (at lower doses) and of norepinephrine and possibly dopamine (at higher doses). Uses: antidepressant, anaglesic for neuropathic pain, fibromyalgia.

3. Duloxetine: potent balanced reuptake inhibitor of both serotonin and norepinephrine. Uses: antidepressant, anaglesic for diabetic peripheral neuropathy, fibromyalgia.

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.