NEUROPATHIC PAIN-HYPERALGESIA & ALLODYNIA MGM

SUMMARY

1. TCA, SNRI, gabapentinoids, opioids, cannabinoids, lamotrigine, mexiletine, lidocaine gel and botulinum toxin-A have been found to relieve dynamic mechanical allodynia, cold allodynia, or pinprick hyperalgesia in peripheral & central neuropathic pain.

2. Pinprick hyperalgesia predicted an overall effect of pregabalin in HIV polyneuropathy and dynamic mechanical allodynia to repetitive pinprick predicted the response to lamotrigine in SCI.

3. Witting and colleagues showed that diffuse noxious inhibitory control, in which a painful stimulus was applied at a distance from a neuropathic pain area, could reduce the perceived intensity of allodynia152.

Reference(s)

Jensen, T.S. and Finnerup, N.B., 2014. Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms. The Lancet Neurology, 13(9), pp.924-935.
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