RENAL-BICARBONATE BALANCE

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SUMMARY

3 methods by which the kidneys increase plasma bicarbonate:

1. Reabsorption of filtered bicarbonate: at the proximal tubule & collecting duct

2. Replacement of filtered phosphate with bicarbonate produced by tubular cells

3. Generation of new bicarbonate by glutamine metabolism within tubular cells

Paste-a3d02c78fc4326028e573b1aff19fc41530f291b.jpg

Image: Cassandra Uy, McMaster Pathiphysiology. [Accessed 7 Apr. 2019].


Reference(s)

Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education