PH & BUFFERING-ACID GENERATION
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SUMMARY
1. Most of the acid comes from CO2 generated by metabolism. This enters solution forming carbonic acid, the process catalyzed by carbonic anhydrase.
2. Metabolism of sulphur-containing amino acids cystine & methionine.
3. Anaerobic metabolism generating lactic acid.
4. Generation of ketone bodies: acetone, acetoacetate, beta-hydroxybutyrate.
Reference(s)
Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education