AUTOREGULATION-PRINCIPLES

From NeuroRehab.wiki

Revision as of 02:30, 21 March 2023 by Dr Appukutty Manickam (talk | contribs) (Imported from text file)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

SUMMARY

1. Regulation exists to control and direct blood flow (BF) to vital organs when necessary (brain, heart, kidneys).
2. Linear relationship between metabolic rate (MR) & BF ⟹ 8x increase MR in skeletal muscle is assoc. with 4x increase in BF.

CONTROL
3. Local BF control: by autoregulation (via myogenic response) & locally produced vasodilator metabolites.
4. Systemic BF control: sympathetic nerves & circulating vasoactive substances.
5. Long-term BF control occurs by changes in the number & size of blood vessels.


Reference(s)

Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education