DIABETES MELLITUS-PATHOPHYSIOLOGY

SUMMARY

1. People are generally born with a degree of insulin resistance which may change with obesity or other factors, but not much over an individual's lifetime.

2. What changes is that beta-cell function & production of insulin in response to insulin-resistance deteriorates over time.

3. Eventually this reaches a stage where glucose levels rise, leading to impaired glucose tolerance then overt diabetes.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].