DIABETES MELLITUS-SECRETAGOGUES
SUMMARY
1. The sulfonylureas and meglitinides increase insulin secretion.
2. Glipizide is a 2nd generation sulfonylurea.
3. Weight gain is a common side effect of sulfonylureas.
4. The half-life of these drugs is long, and hypoglycemia can persist in states of overdose or renal impairment.
5. Meglitinides: These drugs are rapid-acting with a very short half-life (repaglinide, nateglinide). Major effect is on postprandial glucose.
Reference(s)
Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].
