DIABETES INSIPIDUS-INVESTIGATIONS

SUMMARY

Water depravation with hourly serum ADH, plasma & urine osmolality measurements:

1. f(plasma osm) = plasma ADH, where if ADH fails to increase despite serum osm increasing is diagnostic for neurogenic DI.

2. f(plasma ADH) = urine osm, where if osm fails to increase despite ADH increasing is diagnostic for nephrogenic DI.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].