CPPD DEPOSITION DISEASE

SUMMARY

1. Most idiopathic CPPD deposition occurs in patients > 65 years of age and who have underlying joint damage from OA or trauma.

2. When in a patient < 50 years of age, consider: primary hyperparathyroidism, hypomagnesemia, hypophosphatemia, haemochromatosis, hypothyroidism.

3. Presentation ranges from asymptomatic deposition to pseudogout.

4. Chondrocalcinosis is calcification of cartilaginous tissue and is a hint to underlying CPPD.

5. CPPD arthropathy usually affects the knee. Others include wrists, 2^nd& 3^rd MCPJ, shoulders, elbows, and ankles.

6. Look out for the patient with wrist arthritis with Bouchard (PIP) and Heberden (DIP) nodes - screen for hemochromatosis, hyperparathyroidism, and hypothyroidism in patients < 50 years.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].