ANTIBODIES-SPECIFIC ANTINUCLEAR ANTIBODIES

SUMMARY

1. Anti-dsDNA (in high titer), anti-ribosomal P protein and anti-Smith (anti-Sm) are very specific for SLE.

2. Anti-U1-RNP: absence of the antibody excludes MCTD.

3. Antihistone: very sensitive (> 95%) for drug-induced lupus, absence effectively rules out DIL.

4. Anti-Scl-70 is specific for progressive systemic sclerosis.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].