STROKE-tPA EXCLUSION CRITERIA

SUMMARY

TIMING
1. Time of onset uncertain or > 4.5 hours; > 9 hours with perfusion mismatch

PRESENTATION
2. Poor prognosis: coma, fixed, dilated pupils, dense hemiplegia (indicative of large area of infarction)
3. Advanced liver or heart disease

RISK OF HAEMORRHAGE
4. ICH present
5. SAH, septic emboli present
6. BP > 180/110mmHg
7. Patient on anticoagulants, received Heparin within 48 hours, hx of coagulopathy, INR > 1.4
8. Thrombocytopenia

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].