GLOMERULONEPHRITIS-GOODPASTURE SYNDROME

SUMMARY

1. Anti-GBM antibodies in the serum & pulmonary hemorrhage. This disease is not a vasculi­tis.

2. Patients present with an active urine sediment and hemoptysis with dyspnea.

3. Antibodies that attack the glomerular (and sometimes pulmonary) basement membrane(s) are formed in response to an unknown stimulus.

4. Renal biopsy makes the diagnosis by revealing anti-GBM lgG deposited in a linear fashion along the GBM. Anti-GBM antibodies in the serum make the diagnosis.

5. Differentiate from Wagner’s granulomatosis: more likely to be c-ANCA-positive.

6. Treatment of Goodpasture syndrome is plasmapheresis (to remove the antibodies) with immunomodulation (ste­roids & cyclophosphamide).

Reference(s)

Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].