DIURETICS-CARBONIC ANHYDRASE INHIBITORS

SUMMARY

1. Carbonic anhydrase inhibitors (acetazolamide) disrupt the proximal tubule Na⁺/H⁺ counter-transporter by reducing the availabilities of H⁺ in the tubule cells and H₂CO₃^- in the lumen.

2. Then, the Na⁺/H⁺ counter-transporter does not have substrate. Na⁺ is not absorbed and H⁺ is not secreted.

3. A mild diuresis ensues (as well as generation of a metabolic acidosis, similar to proximal, Type 2 RTA).

Reference(s)

Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].