ACUTE KIDNEY INJURY (AKI)-NSAIDs
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Revision as of 11:48, 31 January 2023 by Dr Appukutty Manickam (talk | contribs) (Imported from text file)
SUMMARY
1. Pre-renal failure - by inhibiting prostaglandin production, leading to decreased glomerular perfussion pressure.
2. Hyperkalemia - due to inhibition of renin release from JG apparatus, leading to low aldosterone, due to reduced K+ excreation.
3. NSAIDs also can cause an acute or a chronic interstitial nephritis, with nephrotic-range proteinuria (common) and papillary necrosis (rare).
Reference(s)
Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].
