PULMONARY EMBOLISM-ANTICOAGULANT CONTRAINDICATIONS

SUMMARY

1. Uncorrected major bleeding disorder (thrombocytopenia, hemophilias, liver failure, renal failure)

2. Uncontrolled severe hypertension (systolic > 200 mmHg, diastolic > 140 mmHg)

3. Potential bleeding lesions (active peptic ulcer, esophageal varices, ruptured aneurysm, recent trauma or surgery to head/orbit/spine, recent stroke, intracranial or intraspinal bleed)

4. Repeated falls or unstable gait

5. LMWH is contraindicated in renal clearance < 30 cc/min

6. Concurrent NSAID use: increases risk of GI bleeding; if not contraindicated, stop NSAIDs

Reference(s)

Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].