SODIUM POTASSIUM ATPase

SUMMARY

1. This electrogenic pump catalyzes the hydrolysis of ATP and uses the energy to extrude 3 Na out to bring in 2K into the cell - coupling ratio of 3:2.

2. Made up of alpha and beta subunits.

3. Accounts for 24% of energy usage in cells and 70% in neurons.

4. Up-regulated by increased intracellular Na, thyroxine, aldosterone, insulin.

5. Down-regulated by decreased ATP production, dopamine, oubain, digoxin.

6. Intracellular edema may occur in areas because inadequate oxygenation depresses cell membrane ionic pumps and allows Na to leak into cells.

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.