RENAL-BICARBONATE BALANCE

SUMMARY

3 methods by which the kidneys increase plasma bicarbonate:

1. Reabsorption of filtered bicarbonate: at the proximal tubule & collecting duct

2. Replacement of filtered phosphate with bicarbonate produced by tubular cells

3. Generation of new bicarbonate by glutamine metabolism within tubular cells



Image: Cassandra Uy, McMaster Pathiphysiology. [Accessed 7 Apr. 2019].

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.