MICROCIRCULATION-DETERMINANTS OF HYDROSTATIC PRESSURE

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SUMMARY

TIP: these factors are described by the Poiseuille-Hagen formula. Remember: greater the hydrostatic pressure, the greater the filtration of fluid into the interstitium.

1. Distance along the capillary: going from the arterial to the venule side, the pressure falls from 35 mmHg to 20 mmHg.

2. Resistance at the arterial and venule sides. Remember: Flow = (Pc-Pi)/R, hence, the lower the resistance, the greater the flow and greater the filtration. Important in the glomerulus where control of GFR is through alterations of pre-post capillary resistances.

3. Gravity: arterial & venous pressures are greater below the heart.


Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.