SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)-INVESTIGATIONS
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SUMMARY
1. The ANA is the highest sensitivity for SLE (99% of patients with active disease have a positive test), but poor specificity. Negative ANA basically excludes SLE.
2. Among the subtypes of ANA, anti-dsDNA and anti-Sm in high titers are very specific.
3. Low levels of C3 & C4 signal a flare of SLE.
Reference(s)
Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].
