ANTIBODIES-SPECIFIC ANTINUCLEAR ANTIBODIES
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Revision as of 11:30, 1 January 2023 by Dr Appukutty Manickam (talk | contribs) (Imported from text file)
SUMMARY
1. Anti-dsDNA (in high titer), anti-ribosomal P protein and anti-Smith (anti-Sm) are very specific for SLE.
2. Anti-U1-RNP: absence of the antibody excludes MCTD.
3. Antihistone: very sensitive (> 95%) for drug-induced lupus, absence effectively rules out DIL.
4. Anti-Scl-70 is specific for progressive systemic sclerosis.
Reference(s)
Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].
