RENIN ANGIOTENSIN SYSTEM-ANGIOTENSIN II

SUMMARY

BINDING TO TYPE I RECEPTORS
1. Vasoconstriction of efferent and afferent glomerular arterioles and interlobular artery ⟹ reduction in renal blood flow ⟹ elevation in hydraulic pressure in glomerular capillary ⟹ maintain GFR when RAS is activated by fall in systemic BP.

2. Inflammatory mediator: proinflammatory effect on leukocytes, endothelial cells and vascular smooth-muscle cells.

3. Proliferation of vascular smooth-muscle cells that can potentially increase atherogenesis.

BINDING TO TYPE II RECEPTORS
4. Counteract the classical actions: vasodilation and natriuresis, protects against target-organ damage and HTN.

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.