CARDIAC OUTPUT-DETERMINANTS OF EDV

SUMMARY

REDUCED END-DIASTOLIC VOLUME
1. Reduced ventricular compliance (e.g. MI, infiltrative disease).
2. Pericardial effusion.
3. Reduced venous return to heart, e.g. standing.

INCREASED END-DIASTOLIC VOLUME
4. Stronger atrial contraction.
5. Negative intra-thoracic pressure during inspiration.
6. Increased venous return to heart, e.g. muscle pumps during exercise.

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.