LAMBERT EATON SYNDROME-INVESTIGATION

SUMMARY

1. Voltage-gated calcium channel antibodies (anti-VGCC): not 100% specific. Measure only in those with high pre-test probability.

2. EMG: decremental response (weakening) to rapid stimulation in MG and incremental response (strengthening) in LE syndrome.

3. Check for malignancy - SCC.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].