GUILLAIN BARRE SYNDROME (GBS)-INVESTIGATIONS

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SUMMARY

1. Lumbar puncture: protein-cell (albumino-cytologic) dissociation with high protein concentration and normal WBC count. Protein can take a few days to become elevated. Inflammatory cells suggest alternative diagnosis.

2. NCS: abnormal after 1-2 weeks, abnormal SNAP, CMAP, F-wave.
3. EMG: normal
4. Blood: anti-ganglioside antibodies present. GM-1 (40-50% of GBS), GQ1b (Miller Fisher variant).


Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].

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