ANALGESIC ABUSE NEPHROPATHY

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SUMMARY

1. Typically occurs in a patient with a history of frequent pain.

2. Presents with a low urine specific gravity, minimal proteinuria, sterile pyuria, and an elevated creatinine.

3. Papillary necrosis is the most common ultimate consequence.

4. A noncontrast CT of the kidneys may show the papillary necrosis.

5. Treatment is supportive, with discontinuation of offending analgesics.


Reference(s)

Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].