ACUTE KIDNEY INJURY (AKI)-CANCER

SUMMARY

1. Direct infiltration: by lymphoma, leukemia, or myeloma.

2. Obstruction: particularly from pelvic and abdominal tumors; intratubular uric acid obstruction due to tumor lysis syndrome, methotrexate crystallization.

3. Glomerular disease: minimal change disease Hodgkin disease), membranous GN (solid tumors), amyloidosis (multiple myeloma).

4. Chemotherapy drug toxicity: mitomycin C-induced hemolytic uremic syndrome; cisplatin-induced tubular injury.

5. Hypercalcemia: of malignancy can lead to acute renal failure.

Reference(s)

Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].