RHEUMATOID ARTHRITIS-MANAGEMENT (OTHER NON BIOLOGIC DMARDs)
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SUMMARY
1. Leflunomide: pyrimidine antagonist and may be used as an initial DMARD in patients unable to take MTX. SE: diarrhea, respiratory infections, hepatotoxicity, teratogenicity.
2. Hydroxychloroquine. SE: retinopathy, patients require baseline optometry prior to commencing the drug.
3. Sulfasalazine. SE: sulfa-allergic reactions, myelosuppression, GI disturbance.
Reference(s)
Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].