DIURETICS-CARBONIC ANHYDRASE INHIBITORS

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SUMMARY

1. Carbonic anhydrase inhibitors (acetazolamide) disrupt the proximal tubule Na+/H+ counter-transporter by reducing the availabilities of H+ in the tubule cells and H2CO3- in the lumen.

2. Then, the Na+/H+ counter-transporter does not have substrate. Na+ is not absorbed and H+ is not secreted.

3. A mild diuresis ensues (as well as generation of a metabolic acidosis, similar to proximal, Type 2 RTA).


Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].