ATN-DRUGS & ATN

SUMMARY

1. Amphotericin B causes ATN at a cumulative dose at > 3 gm, causing Type 1 & 2 RTA.
2. Aminoglycosides (AG) cause proximal tubule damage, GFR begins to fall 5-7 days after the start. OD dosing is less nephrotoxic than multi-daily doses. Gentamicin is the most toxic AG.
3. Cisplatin causes a magnesiuria and hypomagnesemia.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].