SODIUM POTASSIUM ATPase
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Revision as of 02:30, 21 March 2023 by Dr Appukutty Manickam (talk | contribs) (Imported from text file)
SUMMARY
1. This electrogenic pump catalyzes the hydrolysis of ATP and uses the energy to extrude 3 Na out to bring in 2K into the cell: coupling ratio of 3:2.
2. Made up of alpha and beta subunits.
3. Accounts for 24% of energy usage in cells and 70% in neurons.
4. Up-regulated by increased intracellular Na, thyroxine, aldosterone, insulin.
5. Down-regulated by decreased ATP production, dopamine, oubain, digoxin.
6. Intracellular edema may occur in areas because inadequate oxygenation depresses cell membrane ionic pumps and allows Na to leak into cells.
Reference(s)
Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education
