PH & BUFFERING-ACID GENERATION

SUMMARY

1. Most of the acid comes from CO₂ generated by metabolism. This enters solution forming carbonic acid, the process catalyzed by carbonic anhydrase.

2. Metabolism of sulphur-containing amino acids cystine & methionine.

3. Anaerobic metabolism generating lactic acid.

4. Generation of ketone bodies: acetone, acetoacetate, beta-hydroxybutyrate.

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.