INTERCELLULAR CONNECTION-GAP JUNCTION
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Revision as of 02:30, 21 March 2023 by Dr Appukutty Manickam (talk | contribs) (Imported from text file)
SUMMARY
1. 3nm tunnels formed by connexons which line up with each other in adjacent cells. Each connexon is made up of 6 protein subunits called connexins.
2. Particular connexin subunits that make up connexons determine their permiability and selectivity.
3. Allows ions, sugars, amino acids, and anything < MW 1000, denies access to larger or negatively charged molecules.
4. Facilitates cell-cell communication.
5. Allow cardiac or smooth muscle to contract simultaneously.
6. Charcot-Marie-Tooth disease: X-linked, peripheral neuropathy assoc. with defective connexin gene.
Reference(s)
Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education
