RHEUMATOID FACTOR AND ANTI-CCP

From NeuroRehab.wiki

Revision as of 20:03, 13 March 2023 by Dr Appukutty Manickam (talk | contribs) (Imported from text file)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

SUMMARY

1. Rheumatoid factor (RF) is an auto-antibody that binds to the Fc region of IgG, positive in 80-85% of patients with RA.

2. Sensitive but not specific as it is present in other diseases: chronic lung disease, chronic infections (TB, HIV, viral hepatitis), Sjogren's, SLE, infectious endocarditis, and hematologic malignancies.

3. The anti-citrullinated cyclic peptide (anti-CCP antibody), is highly specific for RA (97%) and tends to portend a poorer prognosis.

4. The presence of both RF and anti-CCP antibodies is associated with more aggressive RA.


Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].