ANTIBODIES-ANTIPHOSPHOLIPID SYNDROME

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SUMMARY

1. Lupus anticoagulant (LAC): binds to phospholipids and proteins associated with the cell membrane.

2. Lupus anticoagulant is a misnomer, as it is actually a prothrombotic agent.

3. These antibodies increase laboratory coagulation tests such as the APTT but patients are hypercoagulable. Even after dilution, APTT remains elevated indicating the presence of antibodies.

TYPES
3. Anticardiolipin antibodies (lgG or lgM in medium/high titer).

4. Anti-beta2 - glycoprotein 1 antibodies (lgG or lgM at any titer).


Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].

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