ANTIBODIES-ANCA

SUMMARY

1. Antineutrophil Cytoplasmic Antibodies (ANCA): autoimmune antibodies against antigens in the cytoplasm of neutrophils, markers for vasculitis.

2. The combination of c-ANCA+ and anti-PR3+ is very specific for granulomatosis with polyangiitis (GPA; Wegener granulomatosis).

3. c-ANCA+ plus anti-PR3+: think GPA.

4. p-ANCA+ plus anti-MPO+: think MPA, EGPA, Churg-Strauss, pauci-immune RPGN, anti-GBM, and drug-induced.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].