Difference between revisions of "INTRACELLULAR CALCIUM"

Latest revision as of 02:30, 21 March 2023

SUMMARY

1. Ca regulates many physiologic processes: proliferation, neural signaling, learning, contraction, secretion, fertilization.

2. Intracytoplasmic Ca concentration: 100nmol/l; stored in ER and other organelles.

3. Interstitial Ca concentration 12,000x greater, hence Ca has an inward electrochemical gradient.

4. Ca enters cells via ligand-gated, voltage-gated (transient vs. long-standing), stretch-activated channels.

5. Ca removal from cell by: Ca-ATPase, Ca-Na antiport.

6. Ca movement into internal stores via sarcoplasmic or endoplasmic reticulum Ca-ATPase (SERCA) pump.

7. Store-operated Ca channels allow intracellular Ca stores to be replenished.

Reference(s)

Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education

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 ==Reference(s)==
-Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
+Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education
-<br/>Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
-<br/>West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.
 [[Category:Intracellular Calcium]]
 [[Category:Physiology]]