Difference between revisions of "CORONARY ARTERIES-CARDIAC O 2 CONSUMPTION"
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==Reference(s)== | ==Reference(s)== | ||
Barrett, K.E., Barman, S.M | Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education | ||
[[Category:Coronary Arteries]] | [[Category:Coronary Arteries]] | ||
[[Category:Physiology]] | [[Category:Physiology]] |
Latest revision as of 02:30, 21 March 2023
SUMMARY
1. Basal cardiac O2 consumption: 2ml/100g/min (higher than skeletal muscle).
2. Basal cardiac O2 extraction is high and there cannot be increased much further, so increase in cardiac O2 demand must be met by increased coronary flow.
3. Myocardial Work (MW) = SV * PA or aortic pressure (which corresponds to afterload).
4. For unknown reasons, increase in PA or aortic pressure generates more MW than increase in SV.
5. Hence, increased afterload generates more MW than increased preload (why angina is more common with AS than AR).
Reference(s)
Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education