Difference between revisions of "THYROID-PHYSIOLOGY"
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<br/>3. T<sub>4</sub> & T<sub>3</sub> bind to TBG and albumin. | <br/>3. T<sub>4</sub> & T<sub>3</sub> bind to TBG and albumin. | ||
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<br/>4. Only a very small fraction of the total T<sub>4</sub> and total T<sub>3</sub> is unbound, free & active. These are the components that are measured. | <br/>4. Only a very small fraction of the total T<sub>4</sub> and total T<sub>3</sub> is unbound, free & active. These are the components that are measured. | ||
Latest revision as of 02:29, 21 March 2023
SUMMARY
1. TRH in the hypothalamus stimulates the pituitary to secrete TSH, which then stimulates secretion of thyroxine (T4) by the thyroid.
2. Triiodothyronine (T3) is the active hormone; 80% is produced by deiodination of T4 in the peripheral tissues, 20% secreted by the gland.
3. T4 & T3 bind to TBG and albumin.
4. Only a very small fraction of the total T4 and total T3 is unbound, free & active. These are the components that are measured.
Reference(s)
Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].
