Difference between revisions of "HYPERPARATHYROIDISM-PTH"
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===== [[Summary Article|'''SUMMARY''']] ===== | ===== [[Summary Article|'''SUMMARY''']] ===== | ||
FUNCTION | FUNCTION | ||
<br/>1. Stimulates osteoclast activity ⟹ releases bone calcium stores. | <br/>1. Stimulates osteoclast activity ⟹ releases bone calcium stores. | ||
<br/>2. Increases renal tubular calcium absorption + phosphate excretion. | <br/>2. Increases renal tubular calcium absorption + phosphate excretion. | ||
<br/>3. Increases 1,25-dehydroxycholecalciferol (1,25-(OH)<sub>2</sub>D) production by increasing activity of kidney hydroxylase. | <br/>3. Increases 1,25-dehydroxycholecalciferol (1,25-(OH)<sub>2</sub>D) production by increasing activity of kidney hydroxylase. | ||
<br/> | <br/> | ||
<br/>CONTROLLED BY NEGATIVE FEEDBACK | <br/>CONTROLLED BY NEGATIVE FEEDBACK | ||
<br/>4. High serum calcium ⟹ decreased parathyroid PTH production. | <br/>4. High serum calcium ⟹ decreased parathyroid PTH production. | ||
Latest revision as of 02:29, 21 March 2023
SUMMARY
FUNCTION
1. Stimulates osteoclast activity ⟹ releases bone calcium stores.
2. Increases renal tubular calcium absorption + phosphate excretion.
3. Increases 1,25-dehydroxycholecalciferol (1,25-(OH)2D) production by increasing activity of kidney hydroxylase.
CONTROLLED BY NEGATIVE FEEDBACK
4. High serum calcium ⟹ decreased parathyroid PTH production.
Reference(s)
Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].