Difference between revisions of "DIABETES MELLITUS-PATHOPHYSIOLOGY"
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<br/>2. What changes is that beta-cell function & production of insulin in response to insulin-resistance deteriorates over time. | <br/>2. What changes is that beta-cell function & production of insulin in response to insulin-resistance deteriorates over time. | ||
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<br/>3. Eventually this reaches a stage where glucose levels rise, leading to <i>impaired glucose tolerance</i> then overt <i>diabetes.</i> | <br/>3. Eventually this reaches a stage where glucose levels rise, leading to <i>impaired glucose tolerance</i> then overt <i>diabetes.</i> | ||
Latest revision as of 02:29, 21 March 2023
SUMMARY
1. People are generally born with a degree of insulin resistance which may change with obesity or other factors, but not much over an individual's lifetime.
2. What changes is that beta-cell function & production of insulin in response to insulin-resistance deteriorates over time.
3. Eventually this reaches a stage where glucose levels rise, leading to impaired glucose tolerance then overt diabetes.
Reference(s)
Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].
