Difference between revisions of "INTERCELLULAR COMMUNICATION-MECHANISMS"
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==Reference(s)== | ==Reference(s)== | ||
Barrett, K.E., Barman, S.M | Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education | ||
[[Category:Intercellular Communication]] | [[Category:Intercellular Communication]] | ||
[[Category:Physiology]] | [[Category:Physiology]] |
Latest revision as of 02:30, 21 March 2023
SUMMARY
1. Extracellular ligands are called first messengers & intracellular mediators are called second messengers.
2. The receptor-ligand interaction is transduced into secondary response within the cell.
3. Second messengers do the following: ion channel activation, G-protein activation, intracellular enzyme activation, transcription activation.
4. The cell signalling pathway amplifies the primary signal and distributes it to appropriate targets within the cell.
5. The predominant post-translational modification of proteins is phosphorylation via kinases (phosphorylate tyrosine/serine/theornine residues) or phosphatases (remove phosphates from proteins/lipids).
Reference(s)
Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education