Difference between revisions of "RHEUMATOID ARTHRITIS-MANAGEMENT (DMARDs & NON DMARDs)"
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==Reference(s)== | ==Reference(s)== | ||
Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. | Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. [https://amzn.to/3YHrI6K Get it on Amazon.] | ||
<br/>Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. [https://amzn.to/3k7WSW0 Get it on Amazon.] | |||
<br/>Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy. | <br/>Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy. | ||
<br/>Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021]. | <br/>Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021]. | ||
Latest revision as of 20:03, 13 March 2023
SUMMARY
DMARD (first line)
1. Non-biologic agents: hydroxychloroquine, sulfasalazine, methotrexate, cyclosporin, azathioprine.
2. Biologic agents that inhibit TNF (anti-TNF): infliximab, adalimumab, certolizumab, and golimumab are monoclonal antibodies that bind and inactivate TNF.
3. Biologic agents that inhibit other factors: rituximab (anti-CD20 antibodies), anakinra (IL-1 antagonist), tocilizumab (IL-6 antagonist).
NON-DMARD (should only be used as adjuncts)
4. Aspirin (ASA), NSAIDs, COX-2 inhibitors. SE: GI ulceration and bleeding, renal insufficiency, hepatotoxicity, HTN.
5. Corticosteroids. SE: hyperglycemia, immune suppression, osteoporosis, peptic ulcer disease, steroid psychosis. Corticosteroids help to reduce acute inflammation but are less efficacious in the long term.
Reference(s)
Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].
